A 66-year-old woman with metastatic Breast Cancer presents with a persistent, netlike rash on her thigh. Explore the diagnosis behind this cutaneous finding.
A 66-year-old woman with a history of metastatic breast cancer presented with a 1-month history of an asymptomatic, lacy rash on her left thigh. The rash did not vary with changes in environmental temperature. Her breast cancer treatment had been interrupted 3 months before presentation by the coronavirus disease 2019 pandemic. Physical examination was notable for an irregular, broken, netlike pattern of mottling on the left thigh that extended to the knee and lower leg. Testing for autoimmune conditions, thrombophilia, and coagulation disorders was negative. A skin-biopsy sample obtained from the left thigh showed atypical large cells within the vasculature of the reticular dermis that were positive for cytokeratin 7 and GATA-binding protein 3 on immunohistochemical staining. What is the diagnosis?
What is the most likely diagnosis?
Cutaneous metastasis, Dermatology, Livedo racemosa, Metastatic breast cancer, Tumor embolism
