A Deceptive Dermatosis in SLE

Explore a case of a 25-year-old with SLE presenting with erosive plaques and palmar rashes. See how Immunosuppression can alter classic disease presentations.

Syphilis


A 25-year-old woman with systemic lupus erythematosus (SLE) presented with a 3-month history of a rash on her arms, legs, and groin. She had been having condomless sexual intercourse with one male partner during the year preceding presentation. During the 9 months before presentation, she had been taking hydroxychloroquine at a dose of 200 mg daily and prednisolone at a dose of 15 to 40 mg daily to control her SLE. Physical examination was notable for erosive, violaceous plaques in the antecubital fossae, popliteal fossae, and inguinal regions. There were also scaly erythematous patches on both palms. What is the most likely diagnosis?

What is the most likely diagnosis?

Discoid lupus
Extramammary Paget disease
Pemphigus vulgaris
Symmetric drug-related intertriginous and flexural exanthema
Syphilis

Atypical Presentation, Immunosuppression, Infectious Disease, Syphilis, Systemic Lupus Erythematosus

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