A Curious Case of Darier’s Sign

A 10-month-old girl presents with a growing, itchy neck lesion. Stroking the lesion causes it to swell and redden. What is the likely diagnosis?

Solitary Mastocytoma


A previously healthy 10-month-old girl was referred to the pediatric dermatology clinic with a 6-month history of an intermittently itchy and swollen skin lesion on her neck that had gradually increased in size. On physical examination, a thin, well-demarcated, tan plaque was seen on the neck. The lesion was rubbed firmly with a tongue depressor for 5 seconds, and within a few minutes it became edematous with a flare of surrounding erythema — a finding known as Darier’s sign. What is the most likely diagnosis?

What is the most likely diagnosis?

Dermatofibroma
Juvenile Xanthogranuloma (JXG)
Langerhans Cell Histiocytosis (LCH)
Solitary Mastocytoma
Spitz Nevus

Cutaneous Mastocytosis, Darier’s Sign, Dermatology, Pediatrics, Solitary Mastocytoma

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