A Telltale Tongue in HIV

A 29-year-old man with HIV presents with painful tongue lesions. Explore the Differential Diagnosis for oral changes in immunocompromised patients.

Secondary syphilis


A 29-year-old man with well-controlled human immunodeficiency virus infection presented with a 1-week history of a painful, whitish discoloration on his tongue. He also reported a 4-week history of painful ulcers on the scrotum. Physical examination showed smooth, pink, guttate macules on the tongue that were within a white coating that did not wipe off. No rash, ulcer, or lymphadenopathy was seen on genital examination; the reported lesions were presumed to have already resolved. Which of the following is the most likely cause of this patient’s tongue changes?

What is the most likely diagnosis?

Geographic tongue
Lichen Planus
Oral leukoplakia
Secondary syphilis
Squamous Cell Carcinoma

HIV, Oral Lesions, Plaques en prairie fauchée, Secondary syphilis, Treponema pallidum

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