A Butterfly in the Throat?

A 40-year-old man presents with a Sore Throat and unusual butterfly-shaped white plaques in his oropharynx. Explore the diagnostic journey for this rare finding.

Treponema pallidum hemagglutination assay


A 40-year-old man was referred to the otorhinolaryngology clinic with a 1-month history of a sore throat. He reported no upper respiratory symptoms, fever, rash, or genital lesions. The physical examination was notable for nonulcerated white plaques that formed a butterfly shape across the posterior oropharynx, upper uvula, and tonsils. No lymphadenopathy or skin or genital lesions were present. Testing for the human immunodeficiency virus was negative. A biopsy of the plaques showed dense lymphoplasmacytic infiltration. Which of the following tests is most likely to reveal the diagnosis?

What is the most likely diagnosis?

Congo red stain of the biopsy specimen
Flow cytometry of the biopsy specimen
Grocott’s methenamine silver stain of the biopsy specimen
Serum protein electrophoresis
Treponema pallidum hemagglutination assay

Leave a Comment