A 73-year-old woman presents with flank pain. Lab work reveals a high platelet count, and imaging shows a renal infarction. Explore the underlying cause.
A 73-year-old woman presented with a 2-day history of left flank pain. Findings from a physical examination were normal. Laboratory testing was notable for a platelet count of 652,000 per cubic millimeter (reference range, 150,000 to 400,000) with an otherwise normal complete blood count. No previous platelet count was available. Computed tomography of the abdomen with intravenous contrast material showed a filling defect in the left renal artery and a perfusion defect in the left renal cortex, consistent with an occlusive thrombosis of the left renal artery and associated renal infarction. Further testing revealed no evidence of cardioembolic disease, renal artery injury, or inherited thrombophilia. Genetic testing was positive for a genetic variant. Which of the following variants is most likely to be associated with the above findings?
What is the most likely diagnosis?
Essential Thrombocythemia, JAK2, Myeloproliferative Neoplasm, Renal Infarction, Thrombosis
