Rash & Fever: Early HIV Clues

A 26-year-old man presents with a rash, Sore Throat, and fever after recent condomless sex. Explore the diagnosis of acute HIV and its earliest detection.

HIV nucleic acid test


A previously healthy 26-year-old man presented to the emergency department with a 5-day history of an asymptomatic rash, sore throat, fevers, chills, and malaise. On physical examination, scattered, erythematous papules and macules could be seen across the upper chest and anterior neck (left). In the mouth, palatal petechiae, buccal mucosal ulcerations, and pharyngeal erythema were observed (right). The patient reported having had condomless sex with a new partner 2 weeks before presentation. A diagnosis of acute Human Immunodeficiency Virus (HIV) infection was made. Which of the following is the first to become positive after a patient is infected with HIV?

What is the most likely diagnosis?

HIV IgG antibody
HIV IgM antibody
HIV nucleic acid test
p24 antigen
Western Blot

Acute HIV, Exanthem, HIV Diagnosis, HIV nucleic acid test, Seroconversion

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