Puzzling Pneumonia & Eosinophils

A 54-year-old woman with asthma presents with a productive cough, dyspnea, and weight loss. Labs show high eosinophils, and CT shows peripheral Consolidation.

Chronic eosinophilic pneumonia


A 54-year-old woman with asthma and allergic rhinitis presented with a 3-month history of productive cough and dyspnea. She also reported fevers, chills, night sweats, and an unintentional 9-kg (20-lb) weight loss. On lung examination, there was expiratory wheezing and diffuse crackles. Laboratory testing showed pronounced hypereosinophilia. A computed tomography of the chest showed upper lobe–predominant peripheral and subpleural consolidations that spared the perihilar region (shown). Serum testing for IgE against Aspergillus fumigatus, antibodies against coccidioides, and antineutrophil cytoplasmic antibodies was negative. Bronchoscopy with bronchoalveolar lavage was notable for 74% eosinophils in the cell count (reference value, <2) and negative tests for infectious diseases. What is the most likely diagnosis?

What is the most likely diagnosis?

Allergic bronchopulmonary aspergillosis
Chronic eosinophilic pneumonia
Cryptogenic organizing pneumonia
Drug-Induced eosinophilic pneumonia
Pulmonary tuberculosis

Bronchoalveolar Lavage, Chronic eosinophilic pneumonia, Corticosteroids, Eosinophilia, Pulmonary Infiltrates

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