A Curious Case of Gloves and Socks

A young adult with a Rash on his hands and feet has Parvovirus B19. But what is the textbook rash associated with this common childhood virus?

"Slapped cheek" pattern on the face


A 26-year-old man presented to the dermatology clinic with a 1-week history of an asymptomatic rash on his hands and feet. He also reported having had a fever — which had resolved 6 days before presentation — but no joint pains or oral lesions. Physical examination was notable for scattered, partially blanchable macules around the wrists and ankles that merged into erythematous patches on both the ventral (left) and dorsal (right) surfaces of the hands and feet. Serum B19 IgM antibody test and polymerase-chain-reaction assay were positive for parvovirus, and a diagnosis of papular-purpuric “gloves and socks” syndrome in the context of parvovirus B19 infection was made. What is the more classic appearance and distribution of the rash associated with this virus?

What is the most likely diagnosis?

Purpura on the buttocks and lower extremities
“Sandpaper” rash that is accentuated in flexor creases
“Slapped cheek” pattern on the face
Transient salmon-pink maculopapular rash on the trunk
Vesicles on an erythematous base in a dermatomal distribution

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