A 2-year-old boy develops an itchy, blistering rash after a URI and ibuprofen. Explore the diagnosis behind this Autoimmune skin condition.
A previously healthy 2-year-old boy was brought to clinic with a 1-week history of itchy, red spots. Three days before the onset of the rash, the child had had an upper respiratory infection for which he had been given ibuprofen. On physical examination, tense vesicles and edematous pink plaques with central erosions and crust were seen on the patient’s legs, arms, and back. Dense clustering of skin lesions was observed in the axillae and inguinal folds. No mucosal involvement was noted. Histopathological analysis of a skin-biopsy sample obtained from the right lower back showed a subepidermal blister with robust neutrophilic infiltration. Direct immunofluorescence revealed a linear band of IgA along the dermoepidermal junction. What is the most likely diagnosis?
