Annular Rash in an Infant

A 2-month-old boy presents with annular plaques on the face, scalp, and trunk. Explore the diagnosis behind this characteristic rash and Skin Biopsy findings.

Neonatal lupus erythematosus


A previously healthy, full-term, 2-month-old boy was brought to the dermatology clinic with a 2-week history of annular plaques with edematous borders and central crusting on the face, scalp, and trunk. Results of a complete blood count and comprehensive metabolic panel were normal. Examination of a skin-biopsy sample obtained from the baby’s right forehead showed vacuolar interface dermatitis and perivascular and periadnexal lymphocytic infiltrates. Which of the following is the most likely underlying cause of this baby’s findings?

What is the most likely diagnosis?

Cutaneous Langerhans cell histiocytosis
Impetigo
Milia
Neonatal lupus erythematosus
Tinea corporis

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