The Great Imitator Strikes Again

Malignant syphilis
A 42-year-old man with HIV presents with painful, necrotic skin ulcers and systemic symptoms. Explore this rare and severe dermatological manifestation.
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Skin Clues in Severe Immunosuppression

Molluscum contagiosum
A 60-year-old man with advanced HIV presents with unusual facial and eyelid lesions. Explore the diagnosis of these dome-shaped, umbilicated papules.
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Crohn’s Disease: Beyond the Gut

Knife-cut ulcers from Crohn's disease
A 30-year-old with Crohn's disease develops painful genital ulcers. Discover the connection between his gastrointestinal condition and this skin manifestation.
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Landscaper’s Verrucous Lesions

Itraconazole
A 53-year-old landscaper presents with chronic itchy skin lesions. Explore the diagnosis of a rare fungal infection and its appropriate management.
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A Rash Revealing a Deeper Issue

Eruptive xanthomas
A 27-year-old man with obesity develops a rash of pink-yellow papules. Explore the link between skin findings and severe hypertriglyceridemia.
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When a Drug Reaction Turns Serious

Drug reaction with eosinophilia and systemic symptoms
A 30-year-old man develops a rash, fever, and facial edema after taking antibiotics. Explore this case of severe drug hypersensitivity with eosinophilia.
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A Case of Swollen Earlobes and Numbness

Lepromatous Leprosy
Explore the case of a 40-year-old man with painless earlobe swelling, nasal congestion, and sensory loss. Uncover the differential and final diagnosis.
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A Puzzling Case of Facial Nodules

Lupus pernio
A 71-year-old man presents with chronic violaceous nodules on his nose and ears. Explore the diagnosis behind these skin lesions and systemic findings.
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A Mysterious Dark Patch on the Palm

Tinea nigra
A 19-year-old presents with a growing dark spot on her palm. Explore the differential diagnosis, from melanoma to a surprising fungal infection.
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Too Close to the Fire?

Erythema ab igne
A 24-year-old woman develops a strange, reticulated rash on her shins after sitting near a heater. Explore the diagnosis of this heat-related condition.
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