A Puzzling Pruritic Rash

Reactive perforating collagenosis
An 83-year-old woman with diabetes presents with a chronic, itchy rash on her back. Discover the diagnosis behind these unique crateriform lesions.
Read more

When Skin Hardens: A Complex Case

Scleromyxedema
A 53-year-old man presents with a waxy, itchy rash, skin thickening, and dysphagia. Explore a rare diagnosis linked to monoclonal gammopathy.
Read more

An Itchy, Streaky Back Rash

Shiitake mushrooms
A 72-year-old man develops an itchy, flagellate rash on his back. What common food item could be the surprising culprit? Explore this case of dermatitis.
Read more

A Curious Case of Gloves and Socks

"Slapped cheek" pattern on the face
A young adult with a rash on his hands and feet has Parvovirus B19. But what is the textbook rash associated with this common childhood virus?
Read more

Chronic Shin Lesions: A Diagnostic Puzzle

Necrobiosis lipoidica
A 43-year-old woman presents with an 8-year history of growing, asymptomatic yellow-brown plaques on her shins. Explore this case of granulomatous dermatitis.
Read more

A Paradoxical Skin Reaction

Exogenous ochronosis
A 55-year-old woman develops paradoxical skin darkening after using a hydroquinone-based cream for melasma. Explore the diagnosis and management.
Read more

A Blue Tint After Treatment

Dapsone
A 35-year-old on leprosy medication develops anxiety, tremor, and central cyanosis. Discover the unexpected drug reaction causing these alarming symptoms.
Read more

The Symmetrical Drug Rash Mystery

Beta lactam antibiotics
A 42-year-old woman develops a symmetric rash in her skin folds after starting a new medication. Explore the diagnosis of SDRIFE and its common triggers.
Read more

A Veterinarian’s Painful Rash

Interferon-γ release assay
A 59-year-old veterinarian presents with a chronic, painful hand rash. Biopsy is inconclusive, but advanced testing reveals an unexpected infectious cause.
Read more

A Case of Raccoon Eyes & Weight Loss

Vascular fragility owing to infiltration of vessel walls
A 58-year-old man presents with a 2-year history of eyelid lesions, fatigue, and 'raccoon eyes'. Explore the diagnosis behind these classic signs.
Read more