A Tale of Two Limbs

Eisenmenger's syndrome
Explore the clinical puzzle of differential cyanosis and clubbing. Learn why a patient might show signs of low oxygen in their feet but not their hands.
Read more

The Sunburn-Like Rash

Niacin
Explore the causes of a symmetric, scaly, sunburn-like rash. Learn how a specific dietary deficiency can lead to a distinctive photosensitive dermatitis.
Read more

An X-ray of Hardened Skin

Scleroderma
A radiograph of the right arm reveals calcinosis cutis. Explore the differential diagnosis for this finding and discover the underlying systemic condition.
Read more

That Pesky Scalp and Face Rash

Seborrheic dermatitis
Explore a chronic inflammatory skin condition causing scaling and red patches on the scalp, face, and chest. Learn its features and diagnosis.
Read more

Not Jaundice: A Puzzling Discoloration

Diabetes mellitus
Discover the cause of yellow skin discoloration on the palms and soles when jaundice is ruled out. Learn about the link between skin changes and systemic disease.
Read more

Hypercalcemia & Low PTH: A Diagnostic Dilemma

Hodgkin's lymphoma
Explore the differential diagnosis for a patient presenting with hypercalcemia, suppressed PTH, and bilateral hilar lymphadenopathy. A classic clinical puzzle.
Read more

A Mysterious Bleeding Umbilical Nodule

Endometrioma
A woman with a history of dysmenorrhea presents with an intermittently bleeding umbilical nodule. Explore the differential diagnosis for this rare condition.
Read more

A Hairy Situation & A Viral Link

Porphyria cutanea tarda
A patient with chronic Hepatitis C develops facial hair and a photosensitive rash. Explore the diagnosis confirmed by uroporphyrinuria. What's the link?
Read more

A Bluish Bump in the Mouth

Mucocele
A patient presents with a nontender, smooth-walled, translucent, bluish mass on the tongue. Learn about the diagnosis and management of this common oral lesion.
Read more

Chest X-Ray Mystery

Hydropneumothorax
A patient with cirrhosis undergoes repeated thoracentesis. A chest radiograph reveals a collapsed lung and a distinct air-liquid level. What's the diagnosis?
Read more