A Sudden, Swollen, and Cold Leg

Phlegmasia cerulea dolens
An 81-year-old man presents with acute pain, swelling, and coldness in his left leg with an absent pulse. Explore this critical case of extensive thrombosis.
Read more

A Rapid Neurologic Decline

Creutzfeld-Jakob disease
A 54-year-old man presents with a 3-week history of cognitive decline, ataxia, and myoclonus. Explore the diagnosis of this rapidly fatal condition.
Read more

Infant Vomiting & An Abdominal Clue

Pyloric stenosis
A 23-day-old male presents with increasing vomiting, dehydration, and a palpable abdominal mass. Explore this classic pediatric emergency case.
Read more

A Puzzling Pox on the Cheek

Cats
An 11-year-old girl develops an antibiotic-resistant facial ulcer. Explore the diagnosis of a rare zoonotic infection transmitted by a common household pet.
Read more

A Puzzling Case of Fever and a Pulsatile Hand

Infective endocarditis
A 27-year-old presents with fever, weight loss, a heart murmur, and a rare ulnar artery aneurysm. Uncover the underlying systemic diagnosis.
Read more

A Dangerous Rash During Chemo

Ecthyma gangrenosum
A 21-year-old with AML on chemotherapy develops a rapidly progressing skin lesion and fever. What is the diagnosis for this life-threatening condition?
Read more

A Chilling ECG Finding

Osborn wave
A 76-year-old woman is found outdoors. Explore the classic ECG finding associated with hypothermia and its differential diagnoses. Test your knowledge.
Read more

A Dizzying Case of Red Eyes

Cogan's syndrome
A case of a young woman with interstitial keratitis and vestibuloauditory dysfunction. Uncover the diagnosis and management of this rare inflammatory disorder.
Read more

A Toddler’s Fever & Swollen Finger

Herpetic whitlow
A 1-year-old presents with high fever, a swollen finger, and oral ulcers. Explore the differential diagnosis for this common pediatric presentation.
Read more

A Child’s Ulcer After a Trip Abroad

Cutaneous diphtheria
A 5-year-old girl develops nonhealing, ulcerative skin lesions on her legs after a trip to Sierra Leone. Explore the differential diagnosis.
Read more