A Head-to-Toe Red Rash

Erythrodermic psoriasis
A 29-year-old man presents with a chronic, pruritic, and widespread erythematous rash. Explore the differential diagnosis for generalized erythema.
Read more

A Storm of Nodules in the Lungs

Non–small-cell lung cancer
A 56-year-old woman presents with worsening dyspnea. A CT scan reveals countless lung nodules. Explore the workup for this challenging presentation.
Read more

Mimic of Malignancy: A Pulmonary Puzzle

Actinomycosis
A 58-year-old man with cough, weight loss, and lung nodules. See how biopsy findings of 'sulfur granules' lead to an unexpected diagnosis.
Read more

A Puzzle in the Periphery

Polyarteritis nodosa
An 84-year-old man presents with fever, malaise, and painful, blue-black discoloration of his fingers and toes. What is the underlying diagnosis?
Read more

The Mysterious Gray Line on the Gums

Lead poisoning
A 39-year-old man has abdominal pain, constipation, and a strange gray line on his gums. Explore a classic case of heavy metal toxicity.
Read more

The Root Cause of Worsening Hair Loss

Hypothyroidism
A 41-year-old woman presents with 2 years of worsening hair loss, brittle nails, and an enlarged thyroid. Discover the underlying systemic cause.
Read more

Fever, Rash, and Severe Mucositis

Mycoplasma pneumoniae-associated mucositis
A 26-year-old man presents with a fever, cough, and a targetoid rash. His condition worsens with severe mucositis. What is the underlying cause?
Read more

The Mystery of Bloody Tears

Adverse reaction to systemic antibiotics
A 52-year-old man presents with painless bloody tears (hemolacria). Explore the differential diagnosis, from common causes to the ultimate finding in this case.
Read more

Hoarseness & a Curious Neck Mass

Laryngocele
Explore the case of a 58-year-old farmer with chronic hoarseness and a nontender neck mass. Learn about the likely diagnosis and its causes.
Read more

Post-Transplant Anemia Puzzle

Parvovirus B19 infection
A lung transplant recipient presents with progressive dyspnea and severe anemia. Explore the diagnostic challenge of pure red cell aplasia in this case.
Read more