The Ominous Umbilical Nodule

Sister Mary Joseph's nodule
A 73-year-old woman presents with a painful, enlarging umbilical nodule. Explore the differential diagnosis and workup for this concerning physical finding.
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A Farmer’s Persistent Rash

Sporotrichosis
A 65-year-old farmer develops a growing annular rash on his hand and forearm after an injury. Explore this dermatology case of a subacute skin infection.
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The Wood Grain Rash

Erythema gyratum repens
A 73-year-old woman presents with an evolving, pruritic rash. Discover the diagnosis of this rare, wood grain-like eruption and its serious underlying cause.
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Anemia & Low Platelets: A Medical Puzzle

Thrombotic thrombocytopenic purpura
Explore a case of a young man with hemolytic anemia, severe thrombocytopenia, and fragmented red blood cells. Learn about this urgent diagnosis.
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Swallowed Object: Wait or Intervene?

Foreign bodies that have been present for longer than 24 hours
A 3-year-old girl ingests a metal pendant. Explore the clinical decision-making for managing esophageal foreign bodies in children. When is observation safe?
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When Cysts Crowd the Liver

Autosomal dominant polycystic kidney disease
A 51-year-old woman presents with worsening abdominal pain. Exam and imaging reveal an enlarged liver filled with cysts. What is the underlying cause?
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A Child’s Fever & ‘Doughnut’ Lesions

Group A streptococcus
Discover the cause behind a child's sore throat, fever, and classic 'doughnut' lesions. A key clinical sign in pediatric pharyngitis.
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Eye Injury and Distorted Vision

Separation of the iris
A 48-year-old man presents with pain, double vision, and blurred vision after a bungee cord eye injury. Explore the diagnosis and management of this trauma.
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Bilious Emesis in a Neonate

Hirschsprung's disease
A newborn presents with bilious emesis, abdominal distention, and no meconium in 24 hours. Explore this classic case of neonatal bowel obstruction.
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A Puzzling Case of Seizures and Cysts

Neurocysticercosis
An 18-year-old presents with new-onset seizures. An MRI reveals numerous brain cysts. Explore the diagnosis and management of this systemic parasitic infection.
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