Chemotherapy’s Cutaneous Clue

Fluorouracil side effect
A 57-year-old on chemotherapy for colon cancer develops darkening palms. Explore the differential diagnosis for this striking dermatologic finding.
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A Curious Case of Chronic Bloating

Intestinal lipomatosis
A 74-year-old woman presents with chronic bloating. CT reveals unexpected fat-containing lesions throughout her small bowel. What is the diagnosis?
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A Cry-Associated Genital Mass

Hydrocolpos
A 1-day-old girl presents with a soft, protruding genital mass that enlarges with crying. Explore the differential diagnosis and key investigations.
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A Fatal Finding in the Right Atrium

Angiosarcoma
A 66-year-old man presents with shortness of breath and weight loss, leading to a shocking cardiac discovery. Explore this case of rapid hemodynamic collapse.
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The Blue-Gray Man Mystery

Amiodarone-induced skin discoloration
An 81-year-old man on multiple heart medications presents with facial discoloration after a fall. Explore the differential for this unusual skin finding.
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A Rapidly Growing Red Nodule

Merkel-cell carcinoma
An 84-year-old woman presents with a painless, rapidly growing red nodule on her hand. Explore the differential diagnosis for this aggressive skin lesion.
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Fever, Dyspnea & A Painful Rash

Lymphoma
A 53-year-old man presents with a month-long history of relapsing fevers, shortness of breath, and rapidly progressive, painful skin nodules. What's the diagnosis?
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Fever and Rash from a Furry Friend?

Rat bite fever
A 36-year-old woman presents with fever, joint pain, and a rash. Explore a case of a zoonotic infection linked to a common household pet. Learn the diagnosis.
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A Painful, Red Tongue

Pernicious anemia
A 64-year-old man presents with a painful, smooth red tongue and burning lips. Explore the diagnostic process behind these perplexing oral symptoms.
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When Fingertips Harden and Swell

Calcinosis
A 77-year-old with systemic sclerosis presents with painful fingertip swelling. Explore the diagnosis based on hand radiographs showing calcifications.
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