A Young Man with a Clicking Heart

Redundant mitral valve
A 22-year-old presents with palpitations and a midsystolic click. Explore the diagnosis and sudden decompensation from mitral valve disease.
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A Traveler’s Stubborn Skin Ulcer

Cutaneous leishmaniasis
A 19-year-old develops a persistent hand ulcer and tender nodules after working on a farm in Ecuador. What is the diagnosis? Explore this case.
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A Twisted Cause of Pelvic Pain

Fallopian tube torsion
A 19-year-old woman presents with severe abdominal pain. Explore a rare but critical gynecological emergency that mimics other common diagnoses.
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When Skin Lesions Signal Stroke

Hereditary hemorrhagic telangiectasia
A 74-year-old woman presents with sudden weakness. Discover how lesions on her oral mucosa and hands point to a rare genetic cause of her stroke.
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A Palm Reading You Can’t Ignore

Tripe palms
A 73-year-old woman presents with painful, velvety palms. Explore this rare dermatological sign and its serious systemic implications.
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The Split-Colored Newborn

Infant harlequin syndrome
A neonate with a heart condition develops a striking unilateral erythema. Explore this benign, transient vascular phenomenon seen in newborns.
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When Swelling Silences Speech

Sublingual epidermoid cyst
A 73-year-old woman presents with progressive difficulty speaking due to a large, painless swelling on the floor of her mouth. Explore the diagnosis and management.
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The Case of the ‘Rice Body’ Wrist

Mycobacterial tenosynovitis due to Mycobacterium avium complex
A 51-year-old man with diabetes and HIV presents with chronic wrist swelling, pain, and numbness. MRI reveals 'rice bodies,' leading to a rare diagnosis.
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Bleeding Mass on the Great Toe

Acral lentiginous melanoma
A 52-year-old man presents with a rapidly growing, bleeding nodule on his great toe following a minor injury. Explore the differential diagnosis.
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The Great Imitator in an Infant

Congenital syphilis
A 6-month-old girl presents with a perirectal mass, frontal bossing, and severe periostitis on tibial radiograph. Explore the diagnostic workup.
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