A Bite Worse Than Its Bark

Capnocytophaga canimorsus
A 62-year-old asplenic man presents with fever and thrombocytopenia after a dog bite. Explore the life-threatening cause of his sepsis.
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When a Rash Signals Something More

Necrolytic migratory erythema
A 48-year-old man presents with an itchy rash, significant weight loss, and new-onset diabetes. Explore the differential diagnosis for these classic signs.
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Painless Skin Lesions: A Diagnostic Puzzle

Blastic plasmacytoid dendritic-cell neoplasm
A 29-year-old male presents with progressive, painless skin lesions. Explore the diagnostic journey involving biopsy, immunohistochemistry (CD4, CD56), and more.
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A Dangerous Drug Interaction

Ergotism
A 24-year-old on HIV therapy develops severe leg pain after taking migraine medication. Explore a critical drug-drug interaction leading to limb ischemia.
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A Newborn’s Silent, Distended Abdomen

Hirschsprung's disease
A 3-day-old infant presents with vomiting, constipation, and a distended abdomen. What's the underlying cause of this neonatal intestinal obstruction?
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A Blurry Side Effect of Cancer Therapy

Autoimmune keratitis
A 46-year-old on atezolizumab for bladder cancer develops eye pain, photophobia, and blurred vision. Explore this immune-related adverse event.
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A Curious Case of Long Eyelashes

EGFR inhibition
A 53-year-old woman on treatment for appendiceal cancer develops unusually long eyelashes (trichomegaly). Explore the surprising cause of this side effect.
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A Concerning Palatal Ulcer

Extranodal natural killer T-cell lymphoma
A 50-year-old woman with a 3-year history of nasal obstruction presents with a new painless palatal ulcer and a swollen lip. What could be the diagnosis?
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A Deadly Amoeba’s Deceptive Attack

Granulomatous amebic encephalitis
An 82-year-old man presents with weakness and altered mental status. Despite treatment for meningitis, he rapidly declines. What is this rare, fatal brain infection?
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A Case of Painful, Gritty Eyes

Sjögren's syndrome
A 64-year-old woman presents with a 5-month history of photophobia, ocular pain, and a foreign-body sensation. Explore the differential diagnosis.
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