A Fishy Tale of Skin Nodules

Mycobacterium marinum
A 63-year-old woman develops persistent skin nodules on her arms. A biopsy reveals granulomas. Explore the differential diagnosis for this unusual presentation.
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A Family’s Hardened Hands

Punctate palmoplantar keratoderma
A 68-year-old woman presents with a 40-year history of worsening, non-painful papules and plaques on her hands and feet. A family history is key.
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A Curious Case of Leg Swelling

Echinococcal cysts
A 35-year-old man presents with a 6-month history of right leg swelling. Explore the diagnostic journey from physical exam and imaging to the final diagnosis.
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A Sandstorm in the Lungs

Pulmonary alveolar microlithiasis
A 36-year-old woman presents with cough and dyspnea. Her chest x-ray reveals a striking 'sandstorm' pattern of micronodular opacities. What's the diagnosis?
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A Complicated Gestation

Adrenal mass
A 27-year-old pregnant woman presents with new-onset diabetes, hypertension, and signs of Cushing's syndrome. What is the underlying cause?
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Bone Marrow Clues in Sickle Cell Anemia

Hemophagocytosis of sickle cells
A 60-year-old man with sickle cell disease presents with severe anemia. Explore the diagnostic significance of bone marrow findings in this challenging case.
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A Cancer Patient’s Worsening Cough

Bronchoesophageal fistula
A 50-year-old man with lung cancer develops a worsening cough, chest pain, and shortness of breath. Discover the unusual cause of his symptoms.
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Fever and a Strawberry Tongue

Streptococcal pharyngitis
A 5-year-old girl has a high fever, sore throat, and a distinct 'strawberry tongue'. Explore the diagnosis and management of this common pediatric infection.
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Vision Loss and Headaches in SLE

Antiphospholipid syndrome
A 17-year-old with SLE presents with acute vision loss and chronic headaches. Explore the diagnostic process behind this complex ophthalmologic emergency.
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A Child’s Fever and Painful Blisters

Neutrophilic dermatosis
A 7-year-old girl develops fever and widespread painful blisters after a course of penicillin. Explore the diagnostic process for this rare skin condition.
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