A Curious Case of a Dusky Finger

Spider bite
A 53-year-old woman presents with pain, swelling, and a strange, dusky plaque on her finger. Explore the differential diagnosis for this skin lesion.
Read more

When Swollen Gums Signal Systemic Disease

Leukemic infiltration of the gingiva
A 48-year-old woman presents with fatigue and painful, swollen gums. Explore the differential diagnosis for this unusual presentation and its link to hematology.
Read more

An Alarming Case of Headache & Vision Loss

Giant-cell arteritis
A 74-year-old woman presents with headaches, tongue swelling, and sudden blindness. Explore a rare complication of a common systemic vasculitis.
Read more

A Man’s Armor-Like Skin Rash

Carcinoma en cuirasse
A 65-year-old man presents with a 7-month history of painless, sclerotic skin thickening on his chest and arm, mimicking a breastplate of armor.
Read more

An Infant’s Blueberry Muffin Rash

Langerhans-cell histiocytosis
A term infant presents with a 'blueberry muffin' rash. Skin biopsy shows S100+ and CD1a+ cells. What's the diagnosis for this rare neonatal condition?
Read more

A Thorny Problem in Cirrhosis

Spur-cell hemolytic anemia
Explore a case of severe anemia in a patient with cirrhosis. See how hemolysis, lab data, and a key finding on the peripheral smear reveal the diagnosis.
Read more

Violaceous Plaques & a Hidden Virus

Kaposi's sarcoma
A 50-year-old man presents with a new eye lesion and violaceous skin plaques. A positive HIV test reveals a classic opportunistic diagnosis.
Read more

Purplish Plaques: A Hidden Clue

Leukemia cutis
A 65-year-old man presents with painful purplish plaques. Explore a case linking dermatological signs to a serious systemic hematological condition.
Read more

Cyclical Hemoptysis: A Diagnostic Challenge

Thoracic endometriosis
A young woman presents with hemoptysis linked to her menstrual cycle. A CT reveals a lung nodule. Discover the surprising diagnosis in this case study.
Read more

A Curious Case of Skin Darkening

Vitamin B12 deficiency
A 59-year-old man presents with fatigue, a smooth tongue, and darkening skin on his palms and soles. Explore the differential diagnosis for these unusual signs.
Read more