The Great Imitator Strikes Again

Malignant syphilis
A 42-year-old man with HIV presents with painful, necrotic skin ulcers and systemic symptoms. Explore this rare and severe dermatological manifestation.
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Skin Clues in Severe Immunosuppression

Molluscum contagiosum
A 60-year-old man with advanced HIV presents with unusual facial and eyelid lesions. Explore the diagnosis of these dome-shaped, umbilicated papules.
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The Mystery of a Child’s Limp

Legg–Calvé–Perthes disease
A 4-year-old boy presents with hip pain and a limp, but no trauma or fever. Explore the diagnostic process for this common pediatric orthopedic issue.
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An Unwelcome Guest in the Eye

Ophthalmomyiasis
A 53-year-old man develops severe right eye itching after gardening near a farm. Discover the surprising diagnosis behind his symptoms.
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A Fatal Case of Anorexia and Weakness

Emphysematous aortitis due to Clostridium septicum
Explore a case of a 74-year-old man with anorexia and weakness, leading to a rare diagnosis of emphysematous aortitis caused by *Clostridium septicum*.
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A Case of Progressive Eye Swelling

IgG4-related ophthalmic disease
A 67-year-old man presents with a 1-year history of bilateral eye swelling, proptosis, and recent blurry vision. Explore this diagnostic challenge.
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A Decade of Digital Clubbing

Primary hypertrophic osteoarthropathy
A 31-year-old man presents with a 10-year history of digital clubbing and bone pain. Explore the diagnostic journey when common secondary causes are ruled out.
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Crohn’s Disease: Beyond the Gut

Knife-cut ulcers from Crohn's disease
A 30-year-old with Crohn's disease develops painful genital ulcers. Discover the connection between his gastrointestinal condition and this skin manifestation.
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A Puzzling Post-Infectious Rash

Keratoderma blenorrhagicum
A 40-year-old man develops a scaly foot rash, joint pain, and red eyes after an infection. Explore the diagnosis of this classic triad of symptoms.
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Landscaper’s Verrucous Lesions

Itraconazole
A 53-year-old landscaper presents with chronic itchy skin lesions. Explore the diagnosis of a rare fungal infection and its appropriate management.
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