Unexplained Purpura & Blood Cancer

Amyloid purpura
A patient with untreated multiple myeloma develops spontaneous skin lesions. With normal coagulation and mild thrombocytopenia, what's the underlying cause?
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A Hand That Won’t Straighten

Dupuyten's contracture
Explore a condition causing painless, progressive bending of the fingers, often affecting the ring and little fingers. Learn about its causes and treatments.
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A Mysterious Mouth Rash

Secondary syphilis
A patient presents with pseudomembranous lesions and erosions on the tongue, palate, and tonsils. Explore the differential diagnosis for these oral findings.
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Skin Lesions in an Immigrant

Leprosy
A recent immigrant from Pakistan presents with non-pruritic, non-hypoesthetic skin lesions. What is the differential diagnosis? Explore this classic case.
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A Massive, Cystic Liver

Polycystic liver disease
Explore the case of a massive 9-kg liver requiring transplantation. What underlying condition could cause such dramatic organ enlargement?
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Beard Bumps and Bald Patches

Tinea barbae
A patient presents with pustules and hair loss in the beard area. Explore the differential diagnosis and key features of this fungal infection.
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A Devastating Vascular Complication

Calciphylaxis
A patient presents with soft tissue loss at the fingertips. Radiographs reveal severely calcified arteries. Explore this case of vascular calcification and necrosis.
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Clues on the Lips: A GI Mystery

Peutz-Jeghers syndrome
A 12-year-old boy presents with abdominal pain. The key to his diagnosis lies in the unusual mucocutaneous pigmented lesions on his lips. What's the link?
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A Pain in the Foot After Bronchitis

Fluoroquinolone antibiotic
An 81-year-old woman develops foot pain and swelling after bronchitis treatment. Explore the unexpected link between a common medication and Achilles tendon rupture.
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Nasal Septum Perforation: A Clue

Cocaine
A perforated nasal septum is a well-recognized complication of intranasal drug abuse. Discover the most typically associated substance in this clinical case.
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