Skin Changes and Thyrotoxicosis

Thyrotropin receptor antibodies
A 49-year-old woman with a history of Graves' disease presents with skin changes and thyrotoxicosis. Explore the key diagnostic marker for this condition.
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Flank Pain & A Surprising Blood Test

JAK2
A 73-year-old woman presents with flank pain. Lab work reveals a high platelet count, and imaging shows a renal infarction. Explore the underlying cause.
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The Telltale Indentation

Keratoconus
A 53-year-old man's fall reveals a peculiar eye sign and progressive vision loss. Explore the diagnosis behind dome-shaped eyes and eyelid deflection.
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A Child with a Severe Rash & Mucositis

Testing for bacterial and viral respiratory pathogens
An 8-year-old girl presents with a painful rash, oral and genital ulcers, and a cough. Explore the differential diagnosis and the key next step in management.
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Mysterious Fever and Skin Lesions

Intravascular lymphoma
A 53-year-old woman presents with worsening vascular skin lesions, fever, and a very high LDH. What is the underlying diagnosis? Explore this challenging case.
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A New Mass in an Old Lung Cavity

Voriconazole
A 51-year-old man with a history of treated tuberculosis presents with hemoptysis. A new CT scan reveals a concerning mass within an old lung cavity.
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A Welder’s Neurologic Decline

Chelation therapy
A 55-year-old welder develops progressive parkinsonism. With normal labs but key MRI findings in the basal ganglia, what is the underlying cause and treatment?
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The Pressure Behind the Eyes

Elevated opening pressure
A 25-year-old woman with obesity presents with headaches and blurred vision. Discover the key diagnostic finding for idiopathic intracranial hypertension.
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The Paradox of Breathing

Polysomnography
A 34-year-old man presents with dyspnea that worsens when supine. Explore the diagnostic workup for paradoxical breathing and diaphragmatic paralysis.
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A Reaction to Anemia Treatment

Type III hypersensitivity reaction
A 30-year-old male with aplastic anemia develops fever, rash, and joint pain after receiving anti-thymocyte globulin. Explore this hypersensitivity reaction.
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