The Curious Case of Slate-Gray Skin

An 84-year-old man presents with a 5-year history of progressive, diffuse slate-gray skin Pigmentation. Explore the diagnostic workup for this rare condition.

Argyria


An 84-year-old man with benign prostatic hyperplasia who had been admitted to the hospital with acute kidney injury due to obstructive uropathy was noted to have gray skin. The skin changes had been present for 5 years. On physical examination, diffuse slate-gray pigmentation of the skin, particularly on the face, hands and nails, and sclera, was seen. A skin biopsy revealed small, dark granules in the basement membrane of sweat glands and in pilosebaceous units, blood vessels, and elastic fibers in the dermis. What is the diagnosis?

What is the most likely diagnosis?

Amiodarone-induced hyperpigmentation
Argyria
Hemochromatosis
Minocycline-induced hyperpigmentation
Wilson’s disease

Argyria, Dermatology, Heavy Metal Toxicity, Silver, Skin Pigmentation

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