A Mysterious Metabolic Collapse

A 54-year-old man presents with confusion, vomiting, weight loss, and skin darkening. Explore a classic case of Electrolyte Imbalance and endocrine failure.

Primary adrenal insufficiency (Addison's disease)


A 54-year-old man presented to the emergency department with confusion and vomiting. He also reported an unintentional 10 kg weight loss and progressive darkening of his skin over the past 6 months. Laboratory studies showed a serum glucose of 40 mg per deciliter (reference range, 70 to 110 mg per deciliter), sodium of 108 mmol per liter (reference range, 136 to 145), and a potassium of 6.4 mmol per liter (reference range, 3.5 to 5.1). What is the diagnosis?

What is the most likely diagnosis?

Primary adrenal insufficiency (Addison’s disease)
Acanthosis nigricans
Cushing’s disease
Smoker’s melanosis
Solar lentigines

Cortisol, Hyperkalemia, Hyperpigmentation, Hyponatremia, Primary adrenal insufficiency (Addison’s disease)

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