A 24-year-old on HIV therapy develops severe leg pain after taking migraine medication. Explore a critical drug-drug interaction leading to Limb Ischemia.
A 24-year-old woman with a history of HIV, currently on antiretroviral therapy, presented with 2 days of severe, burning leg pain. She had a migraine headache 4 days before presentation for which she was taking ergotamine twice daily. Leg pain extended from toes to midthigh. On physical examination, both legs were cold with absent popliteal and dorsalis pedis pulses. What is the diagnosis?
What is the most likely diagnosis?
CYP3A4 Inhibitor, Drug-Drug Interaction, Ergotism, Limb Ischemia, Vasospasm
