Painless Skin Lesions: A Diagnostic Puzzle

A 29-year-old male presents with progressive, painless Skin Lesions. Explore the diagnostic journey involving biopsy, immunohistochemistry (CD4, CD56), and more.

Blastic plasmacytoid dendritic-cell neoplasm


A 29-year-old male presented with a 6-month history of progressive painless skin lesions over his face, back, trunk, and limbs. He had no systemic symptoms such as night sweats or weight loss. Skin biopsy showed diffuse dermal infiltrate with blast-like cells extending to the hypodermis. Immunohistochemical analysis showed cells that were positive for CD4, CD56, and CD123. What is the diagnosis?

What is the most likely diagnosis?

Lichen planus
Pustular psoriasis
Blastic plasmacytoid dendritic-cell neoplasm
Cutaneous lymphoblastic T-cell lymphoma
Subacute cutaneous lupus erythematosus

Blastic plasmacytoid dendritic-cell neoplasm, CD123, Dermatology, Immunohistochemistry, Skin Lesions

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