When a Rash Signals Something More

A 48-year-old man presents with an itchy rash, significant weight loss, and new-onset diabetes. Explore the Differential Diagnosis for these classic signs.

Necrolytic migratory erythema


A 48-year-old man presented to the dermatology clinic with a 2-month history of an itchy rash that began in the genital region and then progressed to his torso, hands, and legs. He also noted a 13-kg weight loss over the past few months. On examination, he had erythematous patches and plaques at various stages of healing. What is the diagnosis?

What is the most likely diagnosis?

Herpes simplex virus
Acrodermatitis enteropathica
Paraneoplastic pemphigus
Discoid lupus
Necrolytic migratory erythema

Dermatology, Endocrinology, Glucagonoma, Necrolytic migratory erythema, Paraneoplastic syndrome

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