A Rash After a Sore Throat

A 47-year-old man develops a pustular rash on his hands and feet after being treated for pharyngitis. Explore the Differential Diagnosis and key features.

Poststreptococcal pustulosis


A 47-year-old man presented to the emergency department with a 3-day history of a pustular rash on both hands. One week before presentation, he had started treatment with penicillin V potassium for pharyngitis. Physical examination demonstrated a rash as shown, with a similar rash being present on the soles of both of his feet. A punch-biopsy specimen of a palmar lesion was obtained, and histopathological analysis revealed subcorneal pustules and a mononuclear-cell infiltrate in the dermis. What is the diagnosis?

What is the most likely diagnosis?

Poststreptococcal pustulosis
Palmoplantar psoriasis
Jarisch–Herxheimer reaction
Immunoglobulin A pemphigus
Scabies

Dermatology, Group A Streptococcus, Pharyngitis, Poststreptococcal pustulosis, Pustular rash

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