A Curious Case of Glossitis

A 78-year-old man on steroids for vasculitis presents with a painful tongue ulcer. Explore the Differential Diagnosis for oral ulcers in the immunocompromised.

Cytomegalovirus infection


A 78-year-old man with end-stage renal disease, diabetes mellitus, and microscopic polyangiitis, for which he was taking glucocorticoids, presented to the rheumatology clinic with fever, painful glossitis, and taste abnormalities that had persisted for 1 month. Examination of the tongue showed a large, punched-out, painful ulcer. What is the diagnosis?

What is the most likely diagnosis?

Cytomegalovirus infection
Syphilitic chancre
Herpes simplex virus infection
Behcet’s disease
Eosinophilic ulcer

Cytomegalovirus infection, Glucocorticoids, Immunosuppression, Microscopic polyangiitis, Oral ulcer

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