Chemotherapy’s Cutaneous Clue

A 57-year-old on chemotherapy for colon cancer develops darkening palms. Explore the Differential Diagnosis for this striking dermatologic finding.

Fluorouracil side effect


A 57-year-old man with stage 3b colon cancer on adjuvant chemotherapy noticed progressive darkening of his palms that was not associated with redness, scaling, or pain. The plantar aspects of his feet were minimally affected but the remainder of his skin was normal. What is the diagnosis?

What is the most likely diagnosis?

Addison’s disease
Silver toxicity
Ochronosis
Melasma
Fluorouracil side effect

Chemotherapy, Colon Cancer, Dermatology, Fluorouracil side effect, Hyperpigmentation

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