A Curious Case of Tongue Discoloration

A 64-year-old smoker presents with persistent tongue discoloration after antibiotic use. Antifungal treatment was ineffective. What’s the diagnosis and next step?

Counsel patient to stop smoking


A 64-year-old man who reported current use of tobacco presented with a 2-week history of tongue discoloration. He reported no associated dysgeusia or tongue pain. Approximately 21 days before presentation, he had completed a course of clindamycin to treat a periodontal infection. After the tongue discoloration began, a course of fluconazole was prescribed to treat possible oral candidiasis. However, the tongue changes had persisted. Which of the following is the appropriate next step in management?

What is the most likely diagnosis?

Apply topical budesonide
Counsel patient to stop smoking
Perform a biopsy
Prescribe nystatin
Screen for high risk sexual behaviors

Clindamycin, Counsel patient to stop smoking, Hairy tongue, Smoking, Tongue

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