An Infant’s Blueberry Muffin Rash

A term infant presents with a ‘blueberry muffin’ rash. Skin Biopsy shows S100+ and CD1a+ cells. What’s the diagnosis for this rare neonatal condition?

Langerhans-cell histiocytosis


A female infant delivered at term had a “blueberry muffin” rash at birth. Laboratory tests and imaging studies were normal. Skin biopsy showed a dense infiltrate of cells with kidney-shaped nuclei and positive S100+ and CD1a+ on immunohistochemistry. What is the most likely diagnosis?

What is the most likely diagnosis?

Congenital cytomegalovirus infection
Congenital rubella syndrome
Langerhans-cell histiocytosis
Leukemia cutis
Transient myeloproliferative disorder of Down syndrome

Blueberry muffin rash, CD1a, Dermatology, Langerhans-cell histiocytosis, Pediatrics

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