A Colorful Clue in the Colon

A 60-year-old woman with Rheumatoid arthritis presents with diarrhea and nausea. Colonoscopy and biopsy reveal a surprising diagnosis. What could it be?

Gastrointestinal amyloidosis


A 60-year-old woman with a history of rheumatoid arthritis presented with diarrhea, nausea, and anorexia. Endoscopic examination of the colon and biopsy specimens with Congo red staining under polarized light are shown. What is the diagnosis?

What is the most likely diagnosis?

Gastrointestinal Kaposi’s sarcoma
Gastrointestinal amyloidosis
Lynch syndrome
Crohn’s disease
Gastrointestinal leiomyosarcoma

Colonoscopy, Congo red stain, Diarrhea, Gastrointestinal amyloidosis, Rheumatoid arthritis

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