A Curious Case of Blue Sclerae

A 70-year-old man presents with progressive blue discoloration of his sclerae after 15 years on a common medication. What is the diagnosis?

Minocycline-induced pigmentation


A 70-year-old man presented to the ophthalmology clinic with a 1-year history of progressive bluish discoloration of the sclerae of both eyes. He reported no ocular discomfort or blurry vision. He had previously received a diagnosis of an inflammatory arthritis for which he had been taking minocycline for more than 15 years. Examination was notable for bluish discoloration of the sclera of both eyes and pinnae of both ears. Ophthalmologic examination was otherwise normal. What is the diagnosis?

What is the most likely diagnosis?

Osteogenesis imperfecta
Minocycline-induced pigmentation
Ehlers-Danlos syndrome
Primary acquired melanosis
Conjunctival melanoma

Adverse Drug Reaction, Minocycline-induced pigmentation, Ophthalmology, Scleral pigmentation, Tetracycline

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