A Curious Cause of Diffuse Bone Pain

Explore a case of a 65-year-old lung transplant patient with hand swelling and diffuse bone pain. Learn about a rare iatrogenic cause of Periostitis.

Voriconazole-induced periostitis


A 65-year-old woman presented to the rheumatology service with complaints of progressive swelling in both hands and diffuse body pain. She had a history of lung transplantation 8 years earlier, and had received daily antifungal prophylaxis with voriconazole. On examination, there was prominent joint and soft-tissue swelling and pain in both hands, restricted range of motion in both shoulders, and tenderness on palpation of the bony prominences of the shoulders, elbows, neck, lower back, and knees. What is the most likely diagnosis?

What is the most likely diagnosis?

Heterotopic ossification
Post-transplant calcinosis cutis
Malignant fibrous histiocytoma
Voriconazole-induced periostitis
Chronic graft versus host disease polyarthritis

Drug-induced toxicity, Fluorosis, Periostitis, Rheumatology, Voriconazole-induced periostitis

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