A Family’s Hardened Hands

A 68-year-old woman presents with a 40-year history of worsening, non-painful papules and plaques on her hands and feet. A family history is key.

Punctate palmoplantar keratoderma


A 68-year-old woman presented to clinic with a 40-year history of worsening hyperkeratotic non-painful, non-pruritic papules and plaques on her hands and feet. Her mother, son, and granddaughter had similar lesions. What is the diagnosis?

What is the most likely diagnosis?

Erythema multiforme
Punctate palmoplantar keratoderma
Incontinentia pigmenti
Tuberous sclerosis
Syphilis

Dermatology, Genetics, Hereditary, Keratoderma, Punctate palmoplantar keratoderma

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