A Man with Mechanic’s Hands

A 37-year-old man presents with a chronic history of painful, cracked fingertips, muscle weakness, and Fever. Explore the diagnostic journey.

Antisynthetase syndrome


A 37-year-old man presented with a 14-month history of painful, thickened, and cracked skin on the fingertips of both hands. He also had low-grade fevers and muscle weakness. Laboratory testing showed that the creatine kinase level was above 20,000 U per liter (reference range, 51 to 298). What is the diagnosis?

What is the most likely diagnosis?

Psoriasis
Antisynthetase syndrome
Rheumatoid arthritis
Overuse from manual labor
Eczema

Anti-Jo-1, Antisynthetase syndrome, Interstitial Lung Disease, Mechanic’s Hands, Myositis

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