A Mysterious Pain After Chemo

A 56-year-old man with acute leukemia develops severe back pain after chemo. Explore the Differential Diagnosis for this painful hematologic complication.

Bone marrow necrosis


A 56-year-old man with a new diagnosis of acute monoblastic leukemia received induction chemotherapy and subsequently developed disseminated intravascular coagulation and tumor lysis syndrome. While his condition improved, he began having persistent lower back pain. A pelvic bone marrow specimen is as shown. What is the most likely diagnosis?

What is the most likely diagnosis?

Bone marrow necrosis
Megaloblastic anemia
Myelofibrosis
Multiple Myeloma
Essential thrombocythemia

Acute Myeloid Leukemia, Back Pain, Bone marrow biopsy, Bone marrow necrosis, Tumor lysis syndrome

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