A Puzzling Case of Headache and Fever

A 36-year-old man presents with fever, headache, and neck stiffness. Explore the Differential Diagnosis and diagnostic workup for meningitis.

Cryptococcal meningitis


A 36-year-old man presented to the emergency department with a 2-week history of fever, headache, drowsiness, and photophobia. He was previously healthy and was sexually active with men. The physical examination was notable for a temperature of 38.3°C and neck stiffness. Computed tomography of the head was normal. A lumbar puncture was performed. Based on this preparation of the cerebrospinal fluid, what is the diagnosis?

What is the most likely diagnosis?

Neurosyphilis
Cryptococcal meningitis
Lymphoma
Tuberculosis
Hemorrhagic cysts

Cryptococcal meningitis, Cryptococcus neoformans, HIV/Immunosuppression, Lumbar Puncture, Meningitis

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