Abdominal Skin Lesions Post-TACE

An 81-year-old woman with HCC develops painful abdominal Skin Lesions after TACE. What is the most likely cause of this rare complication?

Drug-Eluting Bead Embolism


An 81-year-old woman with a history of hepatitis C virus–related cirrhosis and hepatocellular carcinoma, who was treated 9 days earlier with transarterial chemoembolization with the use of doxorubicin-eluting beads, presented with painful, progressively worsening skin lesions over the abdomen. A skin biopsy revealed epidermal necrosis and occlusion of small vessels in the reticular dermis. What is the most likely cause of the epidermal necrosis?

What is the most likely diagnosis?

Air Embolism
Bacterial Embolism
Drug-Eluting Bead Embolism
Cholesterol Embolism
Tumor Embolism

Drug-Eluting Bead Embolism, Hepatocellular Carcinoma, Nontarget Embolization, Skin Necrosis, Transarterial Chemoembolization

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