Explore a case of a young man with Hemolytic Anemia, severe thrombocytopenia, and fragmented red blood cells. Learn about this urgent diagnosis.
A 35-year-old man presented to the emergency department with a 2-day history of abdominal pain, headache, and brown urine. He was alert and oriented to time, place, and self. He had no purpura or petechiae. Laboratory evaluation revealed a hemoglobin level of 8.6 g per deciliter (normal range, 13.7 to 17.5) and a platelet count of 6000 per cubic millimeter (normal range, 140,000 to 370,000). Levels of indirect bilirubin and lactate dehydrogenase were elevated, haptoglobin was undetectable, and the serum creatinine level was 1 mg per deciliter (88 μmol per liter; normal range, 0.6 to 1.3 mg per deciliter [57 to 115 μmol per liter]). Test results for infection with the human immunodeficiency virus were negative. A peripheral-blood smear showed numerous schistocytes. What is the diagnosis?
What is the most likely diagnosis?
ADAMTS13, Microangiopathic Hemolytic Anemia, Schistocytes, Thrombocytopenia, Thrombotic thrombocytopenic purpura
