Dry Eyes and a Dry Mouth

Sjögren's syndrome
A patient presents with persistent dry eyes (xerophthalmia) and dry mouth (xerostomia). Explore the differential diagnosis and key features of this condition.
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A Chilling Case of Skin Plaques

Cold agglutinins
A patient develops mysterious skin plaques after their heating fails. Discover the underlying cause beyond common cold injuries and hypercoagulability.
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When a Rash Isn’t Just Skin Deep

Henoch-Schönlein purpura
Explore a case of a patient with abdominal pain, arthralgia, and palpable purpura. Learn about the diagnosis and management of this systemic vasculitis.
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A Serologic Clue in Raynaud’s

Anticentromere antibody
Explore the link between secondary Raynaud's phenomenon and systemic sclerosis. Learn which serologic marker is crucial for diagnosis. A key test for rheumatology.
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Mysterious Lumps on Both Elbows

Gout nodulosis
A 70-year-old presents with unusual bilateral fluctuant masses over the elbows. Explore the differential diagnosis and key to this rare final diagnosis.
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Mysterious Crystals in an RA Patient’s Elbow

Cholesterol
A patient with rheumatoid arthritis has an elbow effusion. Aspiration reveals unique rectangular, platelike crystals. What is the diagnosis?
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An Eye-Opening Systemic Disease Clue

Rheumatoid arthritis
A case of corneal perforation with iris prolapse reveals a surprising underlying systemic autoimmune disease. Learn to recognize this critical sign.
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Post-Delivery Rash: A Maternal Link?

Systemic lupus erythematosus
A newborn with Trisomy 21 develops a rash hours after birth. Explore the maternal diagnosis that explains this presentation of neonatal lupus.
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When Joints Bend But Don’t Break

Jaccoud's arthropathy
Explore a rare, non-erosive arthropathy characterized by reducible joint deformities. Learn about its link to SLE and rheumatic fever, distinct from RA.
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A Hard Complication of Dermatomyositis

Soft-tissue calcinosis
A patient with dermatomyositis develops a challenging complication. Can you identify the diagnosis based on the clinical presentation? Test your knowledge.
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