Vanishing Bones: Acro-osteolysis

Lead exposure
A medical case reviewing the resorption of terminal phalanges (acro-osteolysis). Explore the key differential diagnoses, from PVC exposure to frostbite.
Read more

The Mystery of Aching Ears & Eyes

Polychondritis
Explore a case where eye and ear pain are clues to a systemic autoimmune disease. Learn about the diagnosis and management of this rare condition.
Read more

Headache, Jaw Pain, & Scalp Findings

Giant-cell arteritis
A patient presents with headache, jaw claudication, and scalp necrosis. Explore this urgent diagnosis and the risk of permanent vision loss.
Read more

Right Thigh Swelling & Lytic Lesions

Bisphosphonates
A patient with right thigh swelling is found to have lytic lesions and elevated alkaline phosphatase. What is the diagnosis and best course of treatment?
Read more

Postpartum Hypertension & Aortic Disruption

Takayasu's arteritis
A 36-year-old woman develops uncontrolled hypertension post-C-section. Imaging reveals severe bilateral renal artery stenosis and a disrupted aorta. What is it?
Read more

Cyclosporine & A Curious Blister

Gout
A renal transplant patient on cyclosporine presents with a new skin blister. Explore the differential diagnosis for this common post-transplant complication.
Read more

When Kidneys Fail and Systems Flare

Antineutrophil cytoplasmic autoantibody
Explore a complex case of a man with acute renal failure, constitutional symptoms, and multi-organ involvement. Uncover the key autoantibody in this vasculitis.
Read more

Fever, Joint Pain, and a Curious Rash

Erythema marginatum
A 36-year-old man develops fever, shoulder and knee pain, and an evanescent rash after a sore throat. Explore the diagnosis and management.
Read more

Painful Plaques on the Palms

Sweet's syndrome
A 52-year-old woman with rheumatoid arthritis on treatment presents with painful erythematous plaques on her palms and fingers. What is the diagnosis?
Read more

Decoding Skin & Shortness of Breath

Scleroderma
Explore the case of a young man with dyspnea and 'salt-and-pepper' skin changes. Learn about the diagnostic workup for these multisystem symptoms.
Read more