HIV Patient with Headache & Tongue Lesion

A 34-year-old man with HIV presents with headache, fever, confusion, and a large ulcerative tongue lesion. Explore this case of an Opportunistic Infection.

Disseminated coccidioidomycosis


A 34-year-old man with a history of human immunodeficiency virus (HIV) infection presented to the emergency department with a 1-week history of headache, fever, and confusion. On physical examination, a large, ulcerative lesion was noted on his tongue (Panel A). The patient’s CD4 count was 39 cells per cubic millimeter (reference range, 500 to 1450), and his HIV viral load was 197,000 copies per milliliter. A chest radiograph showed patchy infiltrates in both lungs. A biopsy specimen of the tongue lesion was obtained (Panel B). What is the most likely diagnosis?

What is the most likely diagnosis?

Sarcoidosis
Lingual tuberculosis
Disseminated coccidioidomycosis
Disseminated aspergillosis
B-cell lymphoma

Disseminated coccidioidomycosis, Fungal Infection, HIV, Immunosuppression, Opportunistic Infection

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