The Cotton Wool Skull Clue

A patient presents with classic ‘cotton wool’ skull changes on Radiograph. Which lab test is crucial for diagnosing this common metabolic bone disorder?

Alkaline phosphatase


Which laboratory measure would be expected to be most abnormal in this patient?

What is the most likely diagnosis?

Alkaline phosphatase
{beta}2-microglobulin
Cortisol
Insulin-like growth factor 1
Mean corpuscular volume

Alkaline Phosphatase, Bone Remodeling, Cotton wool skull, Osteitis deformans, Paget’s Disease

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