The Great Imitator Strikes Again

A 42-year-old man with HIV presents with painful, necrotic skin ulcers and Systemic Symptoms. Explore this rare and severe dermatological manifestation.

Malignant syphilis


A 42-year-old man with human immunodeficiency virus (HIV) infection presented with painful skin ulcerations and systemic symptoms. Physical exam showed large ulcers with overlying keratosis and crusting scattered across his scalp, face, perineum, and limbs. Laboratory studies showed a CD4 count of 399 cells/mm3. Skin biopsy showed superficial dermal infiltration of lymphocytes, histiocytes, and plasma cells in a lichenoid pattern with psoriasiform epidermal hyperplasia. What is the most likely diagnosis?

What is the most likely diagnosis?

Bacillary angiomatosis
Disseminated histoplasmosis
Lupus vulgaris (tuberculosis luposa)
Malignant syphilis
Norwegian scabies

Dermatology, HIV, Malignant syphilis, Spirochete, Syphilis

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