The Hair-on-End Skull Sign

A non-contrast CT head reveals a thickened calvaria. Explore the Differential Diagnosis for the classic ‘hair-on-end’ sign seen in hemolytic anemias.

Sickle cell disease


What is the most likely cause of these skull radiographic findings?

What is the most likely diagnosis?

Calvarial osteomyelitis
Scalocephaly
Langerhans’ cell histiocytosis
Carpenter’s syndrome
Sickle cell disease

Hair-on-end sign, Hematology, Hemolytic Anemia, Radiology, Sickle Cell Disease

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